Gordon
My opinion for what it is worth. You are going to be fighting two issues. Max GW and CG. The 12 has a limiting GW (he is experimental and that will certainly help) and the Amphibs are not going to help; coupled with the fact that amphibious floats will push the CG forward. You will want to keep the front end as light as possible. Constant speed props, 0-390 engines, Fuel injection, etc will only exacerbate an already forward CG problem. You may find yourself adding lead to the tail to get the CG in range which could further reduce an already limiting useful load. I would lean towards a 0-360 (it will likely have more torque than the 0-340). But keep everything firewall forward as light as possible. Lightweight alternator, starter, ignition, magnesium sump, magnesium flywheel, Catto prop, lightest exhaust possible, etc.
Dynafocal mount, fuel injection, CS prop, Angle Valve engine, could easily add 50 pounds FWF and you don't want that. Get the max Hp you can for the amphibious floats but watch the weight like a hawk. It is all a trade off.
"Guys that build heavy airplanes don't fly them much". I have seen this a lot. Guys that don't worry about weight, claim that just put a bigger engine on it.......well..... after a few years their airplane has 100 hours on it. The guy that builds light likes the way it flies, and after a few years he has 600 hours on his cub.
Best of luck
Bill