It would be great if turbocharged automobile engines were designed, tested, and proven to run continuously for thousands of hours at full power, but they're not.
Our problem is aviation engine manufacturers justifiably refuse to invest enough resources to bring modern materials, manufacturing techniques, and 21st century automotive technology to the GA market. Automobiles get the trickledown benefits from F1, Indy car, and NASCAR because it helps them sell 10s of millions of cars and trucks each year.
It simply isn't worth the investment to develop engines if the total market is for, at best, thousands of GA engines per year. FAA regulations and liability insurance costs don't help.
Heck, they still build and run PT-6s and Garretts with basically the same design as when they were first built in the late 50s and they cost about $1 million each. According to Wiki some 12 million car engines are produced each year. Lycoming has built only 350,000 piston aircraft engines since production began and only 65,000 P&W PT-6s.
It looks to me like battery powered electric engines are likely the only scalable and affordable option for the small GA market. And I still think adding a little extra O2 into the intake manifold wouldn't hurt.