I have never worked on an aviation engine, so my experience is strictly pre computer controled automotive or powersport engines, so my following thoughts are only based on that (limited) experience.
Unless you are willing the change carb jets after switching blends, you will need fuel injection, and probably electronic fuel injection. E10 will be slightly leaner than E0, but close enough so rejeting is usually not required. E20-E30 will definitely require richer jets, but the rest of the fuel system can normally keep up without modification. E85 is run by some hotrodders where it is available. They will set up their car, or motorcycle, ect like the guys running straight alcohol. This requires alcohol carbs with larger passages, much richer jets, and high flow alcohol fuel systems. With automotive engines the compression ratio should be 9:1-9.5:1 with 92 octane E10, to maximize performance, compression ratios of around 12:1 are used with E85. My understanding is that aviation engines use lower compression because of a longer stroke, peak power at a lower RPM and of course the need for a larger safety margin against detonation. Another consideration is that alcohol burns cooler, to the point that alcohol dragsters can idle and run much longer than their gasoline powered counterparts, and I don't know how that would affect an air cooled aviation engine, good or bad. I have no experience working on electronic fuel injection, but I have run E85 in a Suburban with a 5.3 and the only thing I notice is that it burns more fuel, but costs less to fill compared to E10, about a wash. Its amazing to me that they can readily adjust to anything from E0 to E85.